SidaGhanaV1, Main, Exploration, bibRecord, 000226

CD25+ FoxP3+ Memory CD4 T Cells Are Frequent Targets of HIV Infection In Vivo.

Identifieur interne : 000226 ( Main/Exploration ); précédent : 000225; suivant : 000227

CD25+ FoxP3+ Memory CD4 T Cells Are Frequent Targets of HIV Infection In Vivo.

Auteurs : Mkunde Chachage [Allemagne] ; Georgios Pollakis [Royaume-Uni] ; Edmund Osei Kuffour [Allemagne] ; Kerstin Haase [Allemagne] ; Asli Bauer [Allemagne] ; Yuka Nadai [Allemagne] ; Lilli Podola [Allemagne] ; Petra Clowes [Allemagne] ; Matthias Schiemann [Allemagne] ; Lynette Henkel [Allemagne] ; Dieter Hoffmann [Allemagne] ; Sarah Joseph [Royaume-Uni] ; Sabin Bhuju [Allemagne] ; Leonard Maboko [Tanzanie] ; Fred Stephen Sarfo [Ghana] ; Kirsten Eberhardt [Allemagne] ; Michael Hoelscher [Allemagne] ; Torsten Feldt [Allemagne] ; Elmar Saathoff [Allemagne] ; Christof Geldmacher [Allemagne]

Source :

Journal of virology [ 1098-5514 ] ; 2016.

RBID : pubmed:27384654

Descripteurs français

English descriptors

KwdEn :
- CD4-Positive T-Lymphocytes (chemistry), CD4-Positive T-Lymphocytes (virology), DNA, Viral (analysis), DNA, Viral (genetics), Forkhead Transcription Factors (analysis), HIV (classification), HIV (genetics), HIV (isolation & purification), HIV Infections (virology), Humans, Interleukin-2 Receptor alpha Subunit (analysis), Ki-67 Antigen (analysis), Phylogeny, Receptors, CCR5 (analysis), Sequence Analysis, DNA, T-Lymphocyte Subsets (chemistry), T-Lymphocyte Subsets (virology), env Gene Products, Human Immunodeficiency Virus (genetics).
MESH :
- chemical , analysis : DNA, Viral, Forkhead Transcription Factors, Interleukin-2 Receptor alpha Subunit, Ki-67 Antigen, Receptors, CCR5.
- chemistry : CD4-Positive T-Lymphocytes, T-Lymphocyte Subsets.
- classification : HIV.
- chemical , genetics : DNA, Viral, HIV, env Gene Products, Human Immunodeficiency Virus.
- isolation & purification : HIV.
- virology : CD4-Positive T-Lymphocytes, HIV Infections, T-Lymphocyte Subsets.
- Humans, Phylogeny, Sequence Analysis, DNA.

Abstract

Interleukin 2 (IL-2) signaling through the IL-2 receptor alpha chain (CD25) facilitates HIV replication in vitro and facilitates homeostatic proliferation of CD25(+) FoxP3(+) CD4(+) T cells. CD25(+) FoxP3(+) CD4(+) T cells may therefore constitute a suitable subset for HIV infection and plasma virion production. CD25(+) FoxP3(+) CD4(+) T cell frequencies, absolute numbers, and the expression of CCR5 and cell cycle marker Ki67 were studied in peripheral blood from HIV(+) and HIV(-) study volunteers. Different memory CD4(+) T cell subsets were then sorted for quantification of cell-associated HIV DNA and phylogenetic analyses of the highly variable EnvV1V3 region in comparison to plasma-derived virus sequences. In HIV(+) subjects, 51% (median) of CD25(+) FoxP3(+) CD4(+) T cells expressed the HIV coreceptor CCR5. Very high frequencies of Ki67(+) cells were detected in CD25(+) FoxP3(+) memory CD4(+) T cells (median, 27.6%) in comparison to CD25(-) FoxP3(-) memory CD4(+) T cells (median, 4.1%; P < 0.0001). HIV DNA content was 15-fold higher in CD25(+) FoxP3(+) memory CD4(+) T cells than in CD25(-) FoxP3(-) T cells (P = 0.003). EnvV1V3 sequences derived from CD25(+) FoxP3(+) memory CD4(+) T cells did not preferentially cluster with plasma-derived sequences. Quasi-identical cell-plasma sequence pairs were rare, and their proportion decreased with the estimated HIV infection duration. These data suggest that specific cellular characteristics of CD25(+) FoxP3(+) memory CD4(+) T cells might facilitate efficient HIV infection in vivo and passage of HIV DNA to cell progeny in the absence of active viral replication. The contribution of this cell population to plasma virion production remains unclear.

DOI: 10.1128/JVI.00612-16
PubMed: 27384654

Affiliations:

Le document en format XML

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<author><name sortKey="Joseph, Sarah" sort="Joseph, Sarah" uniqKey="Joseph S" first="Sarah" last="Joseph">Sarah Joseph</name>
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<author><name sortKey="Bhuju, Sabin" sort="Bhuju, Sabin" uniqKey="Bhuju S" first="Sabin" last="Bhuju">Sabin Bhuju</name>
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<author><name sortKey="Sarfo, Fred Stephen" sort="Sarfo, Fred Stephen" uniqKey="Sarfo F" first="Fred Stephen" last="Sarfo">Fred Stephen Sarfo</name>
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<author><name sortKey="Saathoff, Elmar" sort="Saathoff, Elmar" uniqKey="Saathoff E" first="Elmar" last="Saathoff">Elmar Saathoff</name>
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<country xml:lang="fr">Allemagne</country>
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<author><name sortKey="Geldmacher, Christof" sort="Geldmacher, Christof" uniqKey="Geldmacher C" first="Christof" last="Geldmacher">Christof Geldmacher</name>
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<author><name sortKey="Pollakis, Georgios" sort="Pollakis, Georgios" uniqKey="Pollakis G" first="Georgios" last="Pollakis">Georgios Pollakis</name>
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<wicri:regionArea>Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Dusseldorf</wicri:regionArea>
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<author><name sortKey="Bauer, Asli" sort="Bauer, Asli" uniqKey="Bauer A" first="Asli" last="Bauer">Asli Bauer</name>
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<author><name sortKey="Nadai, Yuka" sort="Nadai, Yuka" uniqKey="Nadai Y" first="Yuka" last="Nadai">Yuka Nadai</name>
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<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Infectious Diseases and Tropical Medicine, Medical Center of the University of Munich (LMU), Munich</wicri:regionArea>
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<author><name sortKey="Podola, Lilli" sort="Podola, Lilli" uniqKey="Podola L" first="Lilli" last="Podola">Lilli Podola</name>
<affiliation wicri:level="3"><nlm:affiliation>NIMR Mbeya Medical Research Centre, Mbeya, Tanzania Division of Infectious Diseases and Tropical Medicine, Medical Center of the University of Munich (LMU), Munich, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>NIMR Mbeya Medical Research Centre, Mbeya, Tanzania Division of Infectious Diseases and Tropical Medicine, Medical Center of the University of Munich (LMU), Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
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<author><name sortKey="Clowes, Petra" sort="Clowes, Petra" uniqKey="Clowes P" first="Petra" last="Clowes">Petra Clowes</name>
<affiliation wicri:level="3"><nlm:affiliation>NIMR Mbeya Medical Research Centre, Mbeya, Tanzania Division of Infectious Diseases and Tropical Medicine, Medical Center of the University of Munich (LMU), Munich, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>NIMR Mbeya Medical Research Centre, Mbeya, Tanzania Division of Infectious Diseases and Tropical Medicine, Medical Center of the University of Munich (LMU), Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schiemann, Matthias" sort="Schiemann, Matthias" uniqKey="Schiemann M" first="Matthias" last="Schiemann">Matthias Schiemann</name>
<affiliation wicri:level="4"><nlm:affiliation>Institute for Medical Microbiology, Immunology and Hygiene, Helmholtz Center Munich, Technische Universität München, Munich, Germany Clinical Cooperation Groups Antigen-Specific Immunotherapy and Immune-Monitoring, Helmholtz Center Munich, Technische Universität München, Munich, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute for Medical Microbiology, Immunology and Hygiene, Helmholtz Center Munich, Technische Universität München, Munich, Germany Clinical Cooperation Groups Antigen-Specific Immunotherapy and Immune-Monitoring, Helmholtz Center Munich, Technische Universität München, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
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<author><name sortKey="Henkel, Lynette" sort="Henkel, Lynette" uniqKey="Henkel L" first="Lynette" last="Henkel">Lynette Henkel</name>
<affiliation wicri:level="4"><nlm:affiliation>Institute for Medical Microbiology, Immunology and Hygiene, Helmholtz Center Munich, Technische Universität München, Munich, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute for Medical Microbiology, Immunology and Hygiene, Helmholtz Center Munich, Technische Universität München, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
<orgName type="university">Université technique de Munich</orgName>
</affiliation>
</author>
<author><name sortKey="Hoffmann, Dieter" sort="Hoffmann, Dieter" uniqKey="Hoffmann D" first="Dieter" last="Hoffmann">Dieter Hoffmann</name>
<affiliation wicri:level="4"><nlm:affiliation>Institute of Virology, Helmholtz Center Munich, Technische Universität München, Munich, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Virology, Helmholtz Center Munich, Technische Universität München, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
<orgName type="university">Université technique de Munich</orgName>
</affiliation>
</author>
<author><name sortKey="Joseph, Sarah" sort="Joseph, Sarah" uniqKey="Joseph S" first="Sarah" last="Joseph">Sarah Joseph</name>
<affiliation wicri:level="3"><nlm:affiliation>MRC Clinical Trials Unit at UCL, London, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Clinical Trials Unit at UCL, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bhuju, Sabin" sort="Bhuju, Sabin" uniqKey="Bhuju S" first="Sabin" last="Bhuju">Sabin Bhuju</name>
<affiliation wicri:level="1"><nlm:affiliation>Genome Analytics, Helmholtz Centre for Infection Research, Braunschweig, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Genome Analytics, Helmholtz Centre for Infection Research, Braunschweig</wicri:regionArea>
<wicri:noRegion>Braunschweig</wicri:noRegion>
<wicri:noRegion>Braunschweig</wicri:noRegion>
<wicri:noRegion>Braunschweig</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Maboko, Leonard" sort="Maboko, Leonard" uniqKey="Maboko L" first="Leonard" last="Maboko">Leonard Maboko</name>
<affiliation wicri:level="1"><nlm:affiliation>NIMR Mbeya Medical Research Centre, Mbeya, Tanzania.</nlm:affiliation>
<country xml:lang="fr">Tanzanie</country>
<wicri:regionArea>NIMR Mbeya Medical Research Centre, Mbeya</wicri:regionArea>
<wicri:noRegion>Mbeya</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sarfo, Fred Stephen" sort="Sarfo, Fred Stephen" uniqKey="Sarfo F" first="Fred Stephen" last="Sarfo">Fred Stephen Sarfo</name>
<affiliation wicri:level="1"><nlm:affiliation>Kwame Nkrumah University of Science & Technology, Kumasi, Ghana.</nlm:affiliation>
<country xml:lang="fr">Ghana</country>
<wicri:regionArea>Kwame Nkrumah University of Science & Technology, Kumasi</wicri:regionArea>
<wicri:noRegion>Kumasi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Eberhardt, Kirsten" sort="Eberhardt, Kirsten" uniqKey="Eberhardt K" first="Kirsten" last="Eberhardt">Kirsten Eberhardt</name>
<affiliation wicri:level="3"><nlm:affiliation>Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Bernhard Nocht Institute for Tropical Medicine, Hamburg</wicri:regionArea>
<placeName><settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hoelscher, Michael" sort="Hoelscher, Michael" uniqKey="Hoelscher M" first="Michael" last="Hoelscher">Michael Hoelscher</name>
<affiliation wicri:level="3"><nlm:affiliation>Division of Infectious Diseases and Tropical Medicine, Medical Center of the University of Munich (LMU), Munich, Germany German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Infectious Diseases and Tropical Medicine, Medical Center of the University of Munich (LMU), Munich, Germany German Center for Infection Research (DZIF), Partner Site Munich, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Feldt, Torsten" sort="Feldt, Torsten" uniqKey="Feldt T" first="Torsten" last="Feldt">Torsten Feldt</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Dusseldorf, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Dusseldorf</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Düsseldorf</region>
<settlement type="city">Düsseldorf</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Saathoff, Elmar" sort="Saathoff, Elmar" uniqKey="Saathoff E" first="Elmar" last="Saathoff">Elmar Saathoff</name>
<affiliation wicri:level="3"><nlm:affiliation>Division of Infectious Diseases and Tropical Medicine, Medical Center of the University of Munich (LMU), Munich, Germany German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Infectious Diseases and Tropical Medicine, Medical Center of the University of Munich (LMU), Munich, Germany German Center for Infection Research (DZIF), Partner Site Munich, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Geldmacher, Christof" sort="Geldmacher, Christof" uniqKey="Geldmacher C" first="Christof" last="Geldmacher">Christof Geldmacher</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Infectious Diseases and Tropical Medicine, Medical Center of the University of Munich (LMU), Munich, Germany German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany mchachage@nimr-mmrc.org geldmacher@lrz.uni-muenchen.de.</nlm:affiliation>
<country wicri:rule="url">Allemagne</country>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of virology</title>
<idno type="eISSN">1098-5514</idno>
<imprint><date when="2016" type="published">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>CD4-Positive T-Lymphocytes (chemistry)</term>
<term>CD4-Positive T-Lymphocytes (virology)</term>
<term>DNA, Viral (analysis)</term>
<term>DNA, Viral (genetics)</term>
<term>Forkhead Transcription Factors (analysis)</term>
<term>HIV (classification)</term>
<term>HIV (genetics)</term>
<term>HIV (isolation & purification)</term>
<term>HIV Infections (virology)</term>
<term>Humans</term>
<term>Interleukin-2 Receptor alpha Subunit (analysis)</term>
<term>Ki-67 Antigen (analysis)</term>
<term>Phylogeny</term>
<term>Receptors, CCR5 (analysis)</term>
<term>Sequence Analysis, DNA</term>
<term>T-Lymphocyte Subsets (chemistry)</term>
<term>T-Lymphocyte Subsets (virology)</term>
<term>env Gene Products, Human Immunodeficiency Virus (genetics)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ADN viral (analyse)</term>
<term>ADN viral (génétique)</term>
<term>Analyse de séquence d'ADN</term>
<term>Antigène KI-67 (analyse)</term>
<term>Facteurs de transcription Forkhead (analyse)</term>
<term>Humains</term>
<term>Infections à VIH (virologie)</term>
<term>Lymphocytes T CD4+ ()</term>
<term>Lymphocytes T CD4+ (virologie)</term>
<term>Phylogénie</term>
<term>Produits du gène env du virus de l'immunodéficience humaine (génétique)</term>
<term>Récepteurs CCR5 (analyse)</term>
<term>Sous-populations de lymphocytes T ()</term>
<term>Sous-populations de lymphocytes T (virologie)</term>
<term>Sous-unité alpha du récepteur à l'interleukine-2 (analyse)</term>
<term>VIH (Virus de l'Immunodéficience Humaine) ()</term>
<term>VIH (Virus de l'Immunodéficience Humaine) (génétique)</term>
<term>VIH (Virus de l'Immunodéficience Humaine) (isolement et purification)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>DNA, Viral</term>
<term>Forkhead Transcription Factors</term>
<term>Interleukin-2 Receptor alpha Subunit</term>
<term>Ki-67 Antigen</term>
<term>Receptors, CCR5</term>
</keywords>
<keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>ADN viral</term>
<term>Antigène KI-67</term>
<term>Facteurs de transcription Forkhead</term>
<term>Récepteurs CCR5</term>
<term>Sous-unité alpha du récepteur à l'interleukine-2</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>CD4-Positive T-Lymphocytes</term>
<term>T-Lymphocyte Subsets</term>
</keywords>
<keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>HIV</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>DNA, Viral</term>
<term>HIV</term>
<term>env Gene Products, Human Immunodeficiency Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ADN viral</term>
<term>Produits du gène env du virus de l'immunodéficience humaine</term>
<term>VIH (Virus de l'Immunodéficience Humaine)</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>HIV</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>VIH (Virus de l'Immunodéficience Humaine)</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à VIH</term>
<term>Lymphocytes T CD4+</term>
<term>Sous-populations de lymphocytes T</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>CD4-Positive T-Lymphocytes</term>
<term>HIV Infections</term>
<term>T-Lymphocyte Subsets</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Humans</term>
<term>Phylogeny</term>
<term>Sequence Analysis, DNA</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Analyse de séquence d'ADN</term>
<term>Humains</term>
<term>Lymphocytes T CD4+</term>
<term>Phylogénie</term>
<term>Sous-populations de lymphocytes T</term>
<term>VIH (Virus de l'Immunodéficience Humaine)</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Interleukin 2 (IL-2) signaling through the IL-2 receptor alpha chain (CD25) facilitates HIV replication in vitro and facilitates homeostatic proliferation of CD25(+) FoxP3(+) CD4(+) T cells. CD25(+) FoxP3(+) CD4(+) T cells may therefore constitute a suitable subset for HIV infection and plasma virion production. CD25(+) FoxP3(+) CD4(+) T cell frequencies, absolute numbers, and the expression of CCR5 and cell cycle marker Ki67 were studied in peripheral blood from HIV(+) and HIV(-) study volunteers. Different memory CD4(+) T cell subsets were then sorted for quantification of cell-associated HIV DNA and phylogenetic analyses of the highly variable EnvV1V3 region in comparison to plasma-derived virus sequences. In HIV(+) subjects, 51% (median) of CD25(+) FoxP3(+) CD4(+) T cells expressed the HIV coreceptor CCR5. Very high frequencies of Ki67(+) cells were detected in CD25(+) FoxP3(+) memory CD4(+) T cells (median, 27.6%) in comparison to CD25(-) FoxP3(-) memory CD4(+) T cells (median, 4.1%; P < 0.0001). HIV DNA content was 15-fold higher in CD25(+) FoxP3(+) memory CD4(+) T cells than in CD25(-) FoxP3(-) T cells (P = 0.003). EnvV1V3 sequences derived from CD25(+) FoxP3(+) memory CD4(+) T cells did not preferentially cluster with plasma-derived sequences. Quasi-identical cell-plasma sequence pairs were rare, and their proportion decreased with the estimated HIV infection duration. These data suggest that specific cellular characteristics of CD25(+) FoxP3(+) memory CD4(+) T cells might facilitate efficient HIV infection in vivo and passage of HIV DNA to cell progeny in the absence of active viral replication. The contribution of this cell population to plasma virion production remains unclear.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Ghana</li>
<li>Royaume-Uni</li>
<li>Tanzanie</li>
</country>
<region><li>Angleterre</li>
<li>Bavière</li>
<li>District de Düsseldorf</li>
<li>District de Haute-Bavière</li>
<li>Grand Londres</li>
<li>Hambourg</li>
<li>Rhénanie-du-Nord-Westphalie</li>
</region>
<settlement><li>Düsseldorf</li>
<li>Hambourg</li>
<li>Londres</li>
<li>Munich</li>
</settlement>
<orgName><li>Université technique de Munich</li>
</orgName>
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<tree><country name="Allemagne"><noRegion><name sortKey="Chachage, Mkunde" sort="Chachage, Mkunde" uniqKey="Chachage M" first="Mkunde" last="Chachage">Mkunde Chachage</name>
</noRegion>
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<name sortKey="Clowes, Petra" sort="Clowes, Petra" uniqKey="Clowes P" first="Petra" last="Clowes">Petra Clowes</name>
<name sortKey="Eberhardt, Kirsten" sort="Eberhardt, Kirsten" uniqKey="Eberhardt K" first="Kirsten" last="Eberhardt">Kirsten Eberhardt</name>
<name sortKey="Feldt, Torsten" sort="Feldt, Torsten" uniqKey="Feldt T" first="Torsten" last="Feldt">Torsten Feldt</name>
<name sortKey="Geldmacher, Christof" sort="Geldmacher, Christof" uniqKey="Geldmacher C" first="Christof" last="Geldmacher">Christof Geldmacher</name>
<name sortKey="Haase, Kerstin" sort="Haase, Kerstin" uniqKey="Haase K" first="Kerstin" last="Haase">Kerstin Haase</name>
<name sortKey="Henkel, Lynette" sort="Henkel, Lynette" uniqKey="Henkel L" first="Lynette" last="Henkel">Lynette Henkel</name>
<name sortKey="Hoelscher, Michael" sort="Hoelscher, Michael" uniqKey="Hoelscher M" first="Michael" last="Hoelscher">Michael Hoelscher</name>
<name sortKey="Hoffmann, Dieter" sort="Hoffmann, Dieter" uniqKey="Hoffmann D" first="Dieter" last="Hoffmann">Dieter Hoffmann</name>
<name sortKey="Kuffour, Edmund Osei" sort="Kuffour, Edmund Osei" uniqKey="Kuffour E" first="Edmund Osei" last="Kuffour">Edmund Osei Kuffour</name>
<name sortKey="Nadai, Yuka" sort="Nadai, Yuka" uniqKey="Nadai Y" first="Yuka" last="Nadai">Yuka Nadai</name>
<name sortKey="Podola, Lilli" sort="Podola, Lilli" uniqKey="Podola L" first="Lilli" last="Podola">Lilli Podola</name>
<name sortKey="Saathoff, Elmar" sort="Saathoff, Elmar" uniqKey="Saathoff E" first="Elmar" last="Saathoff">Elmar Saathoff</name>
<name sortKey="Schiemann, Matthias" sort="Schiemann, Matthias" uniqKey="Schiemann M" first="Matthias" last="Schiemann">Matthias Schiemann</name>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Pollakis, Georgios" sort="Pollakis, Georgios" uniqKey="Pollakis G" first="Georgios" last="Pollakis">Georgios Pollakis</name>
</noRegion>
<name sortKey="Joseph, Sarah" sort="Joseph, Sarah" uniqKey="Joseph S" first="Sarah" last="Joseph">Sarah Joseph</name>
</country>
<country name="Tanzanie"><noRegion><name sortKey="Maboko, Leonard" sort="Maboko, Leonard" uniqKey="Maboko L" first="Leonard" last="Maboko">Leonard Maboko</name>
</noRegion>
</country>
<country name="Ghana"><noRegion><name sortKey="Sarfo, Fred Stephen" sort="Sarfo, Fred Stephen" uniqKey="Sarfo F" first="Fred Stephen" last="Sarfo">Fred Stephen Sarfo</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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Le SIDA au Ghana (serveur d'exploration)

CD25+ FoxP3+ Memory CD4 T Cells Are Frequent Targets of HIV Infection In Vivo.

CD25+ FoxP3+ Memory CD4 T Cells Are Frequent Targets of HIV Infection In Vivo.

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	Le SIDA au Ghana (serveur d'exploration)
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